The PTPRJ Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD148, DEP1, HPTPeta, and PTPRJ. This antibody recognizes Human, Mouse, and Rat antigen. The PTPRJ Polyclonal Antibody has been validated for the following applications: ELISA, and Immunohistochemistry.
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene